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Buy diazepam online uk, first marketed as Valium, is a medicine of the benzodiazepine family that acts as an anxiolytic.[9] It is commonly used to treat a range of conditions, including anxietyseizuresalcohol withdrawal syndromebenzodiazepine withdrawal syndromemuscle spasmsinsomnia, and restless legs syndrome.[9] It may also be used to cause memory loss during certain medical procedures.[10][11] It can be taken by mouthinserted into the rectuminjected into muscleinjected into a vein or used as a nasal spray.[5][11] When given into a vein, effects begin in one to five minutes and last up to an hour.[11] By mouth, effects begin after 15 to 60 minutes. Buy diazepam online uk free shipping available

Common side effects include sleepiness and trouble with coordination.[7][11] Serious side effects are rare.[9] They include suicide, decreased breathing, and an increased risk of seizures if used too frequently in those with epilepsy.[9][11][13] Occasionally, excitement or agitation may occur.[14][15] Long-term use can result in tolerancedependence, and withdrawal symptoms on dose reduction.[9] Abrupt stopping after long-term use can be potentially dangerous.[9] After stopping, cognitive problems may persist for six months or longer.[14] It is not recommended during pregnancy or breastfeeding.[11] Its mechanism of action works by increasing the effect of the neurotransmitter gamma-aminobutyric acid (GABA).[14]

Diazepam was patented in 1959 by Hoffmann-La Roche.[9][16][17] It has been one of the most frequently prescribed medications in the world since its launch in 1963.[9] In the United States it was the best-selling medication between 1968 and 1982, selling more than 2 billion tablets in 1978 alone.[9] In 2018, it was the 115th most commonly prescribed medication in the United States, with more than 6 million prescriptions.[18][19] In 1985 the patent ended, and there are now more than 500 brands available on the market.[9] It is on the World Health Organization’s List of Essential Medicines.[2

Caution > buy diazepam online uk

  • Benzodiazepine abuse and misuse should be guarded against when prescribed to those with alcohol or drug dependencies or who have psychiatric disorders.[50]
  • Pediatric patients
    • Less than 18 years of age, this treatment is usually not indicated, except for treatment of epilepsy, and pre- or postoperative treatment. The smallest possible effective dose should be used for this group of patients.[51]
    • Under 6 months of age, safety and effectiveness have not been established; diazepam should not be given to those in this age group.[29][51]
  • Elderly and very ill patients can possibly suffer apnea or cardiac arrest. Concomitant use of other central nervous system depressants increases this risk. The smallest possible effective dose should be used for this group of people.[51][52] The elderly metabolise benzodiazepines much more slowly than younger adults, and are also more sensitive to the effects of benzodiazepines, even at similar blood plasma levels. Doses of diazepam are recommended to be about half of those given to younger people, and treatment limited to a maximum of two weeks. Long-acting benzodiazepines such as diazepam are not recommended for the elderly.[14] Diazepam can also be dangerous in geriatric patients owing to a significant increased risk of falls.[53]
  • Intravenous or intramuscular injections in hypotensive people or those in shock should be administered carefully and vital signs should be monitored.[52]
  • Benzodiazepines such as diazepam are lipophilic and rapidly penetrate membranes, so rapidly cross over into the placenta with significant uptake of the drug. Use of benzodiazepines including diazepam in late pregnancy, especially high doses, can result in floppy infant syndrome.[54] Diazepam when taken late in pregnancy, during the third trimester, causes a definite risk of a severe benzodiazepine withdrawal syndrome in the neonate with symptoms including hypotonia, and reluctance to suck, to apnoeic spells, cyanosis, and impaired metabolic responses to cold stress. Floppy infant syndrome and sedation in the newborn may also occur. Symptoms of floppy infant syndrome and the neonatal benzodiazepine withdrawal syndrome have been reported to persist from hours to months after birth.

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