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JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as “incense blends”.
As a full agonist at both the CB1 and CB2 cannabinoid receptors, this chemical compound is classified as an analgesic medication. The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis.
These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling. As the cause is poorly understood in chronic pain states, more research and development must be done before the therapeutic potential of this class of biologic compounds can be realized
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JWH 018, or “5F-AMB” is a synthetic cannabinoid that occurs naturally in some pine trees. Also called alpha-methylfentanyl, the drug binds with the opioid receptor in the brain and causes an intense high. Chemically, JWH 018 has two isomers: JWH-018 and JWH-073. 5F-AMB and JWH-018 are structurally very different. Both of these isomers have been sold as legal alternatives to marijuana. Both JWH-018 and JWH-073 are semisynthetic, meaning they use a series of chemical steps to manipulate the basic elements of the phenethylamine molecule to create chemicals that are not found in nature. The end result is a chemical with similar effects to marijuana. 5F-AMB, or “JWH-018” is a more potent analog of JWH-018. However, 5F-AMB is actually considered a schedule III controlled substance. What Is JWH 018 Most Commonly Called?
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JWH-018 is the active component of synthetic marijuana and is both a legal and illegal drug. The name JWH-018 came about because the people that invented it named it after another number. The first time that JWH-018 was synthesized was in 1995 by a man named Giuseppe Pellegrino. The major goal was to obtain a natural-sounding chemical that was not illegal but was legal and which generated high THC concentrations. He set out to replicate the major effects of THC and other cannabinoids. jwh-018 alternatives like JWH-015, JWH-019 are available on demand. These effects, for instance, include the psychoactive effects of altered perception, euphoria and perception of time slowing down, the perception of increased heart rate, an increase in blood flow, and a loss of the perception of pain. But JWH-018 is not a pure THC analog. What Is JWH 018 Most Commonly Called?
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